rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0026473,
umls-concept:C0028128,
umls-concept:C0040048,
umls-concept:C0086418,
umls-concept:C0136157,
umls-concept:C0185117,
umls-concept:C0220781,
umls-concept:C0332152,
umls-concept:C0441655,
umls-concept:C1522492,
umls-concept:C1883254,
umls-concept:C2911684
|
pubmed:issue |
11
|
pubmed:dateCreated |
1999-3-5
|
pubmed:abstractText |
Nitric oxide (NO) has antithrombotic properties by regulating platelet function, whereas direct effects on plasmatic coagulation are rarely described. In sepsis and inflammation, when synthesis of NO, oxygen radicals and toxic metabolites is crucial, the expression of tissue factor (TF) on monocytes stimulated by lipopolysaccharides (LPS) induces intravascular coagulation. This study was performed to examine the influence of NO and the NO-dependent metabolite peroxynitrite on LPS-induced TF expression and activity in human monocytes.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0342-4642
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
24
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1199-208
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9876984-Dose-Response Relationship, Drug,
pubmed-meshheading:9876984-Drug Evaluation, Preclinical,
pubmed-meshheading:9876984-Flow Cytometry,
pubmed-meshheading:9876984-Free Radical Scavengers,
pubmed-meshheading:9876984-Gene Expression Regulation,
pubmed-meshheading:9876984-Humans,
pubmed-meshheading:9876984-Lipopolysaccharides,
pubmed-meshheading:9876984-Monocytes,
pubmed-meshheading:9876984-Nitrates,
pubmed-meshheading:9876984-Nitric Oxide,
pubmed-meshheading:9876984-Oxidants,
pubmed-meshheading:9876984-Thromboplastin
|
pubmed:year |
1998
|
pubmed:articleTitle |
Nitric oxide inhibits tissue factor synthesis, expression and activity in human monocytes by prior formation of peroxynitrite.
|
pubmed:affiliation |
Department of Anesthesiology and Critical Care Medicine, Charité-Virchow-Clinic, Humboldt University, Berlin, Germany.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|