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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-2-2
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pubmed:abstractText |
Treatment with the beta-blocker carvedilol leads to an improvement of outcome and ejection fraction in heart failure. These effects occur without affecting the number of beta-adrenergic receptors, as determined in right ventricular biopsies from patients with heart failure. This study was aimed at investigating the effects of carvedilol on beta-adrenergic signal transduction alterations in a model of left ventricular pressure overload, which is characterized by sympathetic activation and a desensitized beta-adrenergic signal transduction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylyl Imidodiphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella,
http://linkedlifedata.com/resource/pubmed/chemical/carvedilol
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
146-55
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9876327-Adenylate Cyclase,
pubmed-meshheading:9876327-Adenylate Cyclase Toxin,
pubmed-meshheading:9876327-Adrenergic beta-Agonists,
pubmed-meshheading:9876327-Adrenergic beta-Antagonists,
pubmed-meshheading:9876327-Animals,
pubmed-meshheading:9876327-Animals, Genetically Modified,
pubmed-meshheading:9876327-Binding, Competitive,
pubmed-meshheading:9876327-Carbazoles,
pubmed-meshheading:9876327-Cardiomyopathy, Dilated,
pubmed-meshheading:9876327-Down-Regulation,
pubmed-meshheading:9876327-Forskolin,
pubmed-meshheading:9876327-GTP-Binding Protein alpha Subunits, Gi-Go,
pubmed-meshheading:9876327-Guanylyl Imidodiphosphate,
pubmed-meshheading:9876327-Heart Rate,
pubmed-meshheading:9876327-Isoproterenol,
pubmed-meshheading:9876327-Male,
pubmed-meshheading:9876327-Neuropeptide Y,
pubmed-meshheading:9876327-Pertussis Toxin,
pubmed-meshheading:9876327-Propanolamines,
pubmed-meshheading:9876327-Rats,
pubmed-meshheading:9876327-Rats, Sprague-Dawley,
pubmed-meshheading:9876327-Receptors, Adrenergic, beta,
pubmed-meshheading:9876327-Signal Transduction,
pubmed-meshheading:9876327-Virulence Factors, Bordetella
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pubmed:year |
1998
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pubmed:articleTitle |
Beta-adrenergic signal transduction following carvedilol treatment in hypertensive cardiac hypertrophy.
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pubmed:affiliation |
Klinik III für Innere Medizin der Universität zu Köln, Germany. Michael.Boehm@Medizin.Uni-Koeln.De
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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