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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-5-18
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pubmed:abstractText |
Recently a new type of proteins modulating the pharmacological profile of the calcitonin receptor-like receptor (CRLR) were identified. The receptor-activity-modifying proteins (RAMPs) were shown to be essential for the expression of a functional CRLR and furthermore the RAMPs seemed to modify ligand selectivity of CRLR: coexpression of CRLR and RAMP1 resulted in a CGRP1 type of receptor while an adrenomedullin receptor resulted when CRLR and RAMP2 were coexpressed. In the present study significant molecular expression of CRLR concomitant with RAMP1, 2 and 3 were demonstrated in human meningeal, cerebral and temporal arteries by use of reverse transcriptase polymerase chain reactions (RT-PCR). These findings support previous studies demonstrating functional CGRP1 receptors in human cranial arteries. Furthermore the present study suggests the potential for functional adrenomedullin receptors in human cranial arteries.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CALCRL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Receptor-Like Protein,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/RAMP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RAMP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activity-Modifying...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activity-Modifying...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activity-Modifying Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitonin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
258
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9876047-Calcitonin Receptor-Like Protein,
pubmed-meshheading:9876047-Cerebral Arteries,
pubmed-meshheading:9876047-DNA, Complementary,
pubmed-meshheading:9876047-Electrophoresis, Agar Gel,
pubmed-meshheading:9876047-Gene Expression,
pubmed-meshheading:9876047-Humans,
pubmed-meshheading:9876047-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:9876047-Membrane Proteins,
pubmed-meshheading:9876047-Meningeal Arteries,
pubmed-meshheading:9876047-Polymerase Chain Reaction,
pubmed-meshheading:9876047-Protein Isoforms,
pubmed-meshheading:9876047-RNA, Messenger,
pubmed-meshheading:9876047-Receptor Activity-Modifying Protein 1,
pubmed-meshheading:9876047-Receptor Activity-Modifying Protein 2,
pubmed-meshheading:9876047-Receptor Activity-Modifying Proteins,
pubmed-meshheading:9876047-Receptors, Calcitonin,
pubmed-meshheading:9876047-Temporal Arteries
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pubmed:year |
1998
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pubmed:articleTitle |
Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries.
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pubmed:affiliation |
Department of Pharmacology, The Royal Danish School of Pharmacy, Copenhagen. ansa@mail.dfh.dk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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