Linked Life Data

9874156

Source:http://linkedlifedata.com/resource/pubmed/id/9874156

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-3-29
pubmed:abstractText
The in vivo measurement of electrically-evoked dopamine overflow was measured for the first time in the striatum of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets using fast cyclic voltammetry at untreated carbon-fibre microelectrodes, (7 microm, o.d.). The identity of dopamine was confirmed using electrochemical, pharmacological and histological criteria and complied with rat data from earlier studies. Dopamine overflow depended on the intensity, number of pulses, and frequency of the applied stimuli. Maximum dopamine overflow occurred using 1.0-2.0 mA, 200 micros pulse width, 150-200 pulses at 80-120 Hz stimulation of the medial forebrain bundle. Evoked dopamine overflow in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated marmosets showed a similar electrochemical and pharmacological profile compared to healthy controls, albeit the concentration detected was significantly reduced. The catecholamine uptake blocker, nomifensine, significantly increased the dopamine signal in control marmosets. However, in contrast, nomifensine had no significant effect on evoked dopamine overflow in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated marmosets. Apart from demonstrating that fast cyclic voltammetry with electrical stimulation can be reliably used to monitor dopamine overflow within the primate brain, our results describe for the first time the technical prerequisites for the fast cyclic voltammetric technique in the non-human primate brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0165-0270
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
201-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9874156-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, pubmed-meshheading:9874156-Animals, pubmed-meshheading:9874156-Callithrix, pubmed-meshheading:9874156-Caudate Nucleus, pubmed-meshheading:9874156-Corpus Striatum, pubmed-meshheading:9874156-Dopamine, pubmed-meshheading:9874156-Dopamine Agents, pubmed-meshheading:9874156-Dopamine Antagonists, pubmed-meshheading:9874156-Dopamine Uptake Inhibitors, pubmed-meshheading:9874156-Electric Stimulation, pubmed-meshheading:9874156-Electrochemistry, pubmed-meshheading:9874156-Female, pubmed-meshheading:9874156-Male, pubmed-meshheading:9874156-Medial Forebrain Bundle, pubmed-meshheading:9874156-Nomifensine, pubmed-meshheading:9874156-Putamen, pubmed-meshheading:9874156-Reference Values, pubmed-meshheading:9874156-Sulpiride, pubmed-meshheading:9874156-Tyrosine 3-Monooxygenase
pubmed:year
1998
pubmed:articleTitle
Pharmacological characterisation of dopamine overflow in the striatum of the normal and MPTP-treated common marmoset, studied in vivo using fast cyclic voltammetry, nomifensine and sulpiride.
pubmed:affiliation
Institute of Physiology, University of Munich, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't