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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1999-1-21
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pubmed:abstractText |
Hybrid molecules built up by covalent coupling of aminopropanol derivatives (especially pindolol) with antidepressant drugs like fluoxetine, paroxetine or milnacipran were found to be potent and silent 5-HT1A antagonists (KB < 1 nM for 7c and 9a).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3423-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9873746-Animals,
pubmed-meshheading:9873746-Drug Design,
pubmed-meshheading:9873746-Mice,
pubmed-meshheading:9873746-Penbutolol,
pubmed-meshheading:9873746-Pindolol,
pubmed-meshheading:9873746-Propranolol,
pubmed-meshheading:9873746-Receptors, Serotonin,
pubmed-meshheading:9873746-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:9873746-Serotonin Antagonists,
pubmed-meshheading:9873746-Serotonin Uptake Inhibitors,
pubmed-meshheading:9873746-Stereoisomerism
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pubmed:year |
1998
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pubmed:articleTitle |
Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors.
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pubmed:affiliation |
Medicinal Chemistry, Centre de Recherche Pierre Fabre, Castres, France. michel.perez@pierre-fabre.com
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pubmed:publicationType |
Journal Article
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