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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0010762,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0031727,
umls-concept:C0205054,
umls-concept:C0205216,
umls-concept:C0243077,
umls-concept:C1366876,
umls-concept:C1415645,
umls-concept:C1456380,
umls-concept:C1833235
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|
pubmed:issue |
22
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|
pubmed:dateCreated |
1999-1-26
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|
pubmed:abstractText |
Pyrimidine analogs of the pyrimidinylimidazole class of CSBP/p38 kinase inhibitors were prepared in an effort to reduce the potent inhibition of hepatic cytochrome P450 observed for the pyridinyl compounds. The substitution of pyrimidin-4-yl, 2-methoxypyrimidin-4-yl, or 2-methylaminopyrimidin-4-yl for pyridin-4-yl effectively dissociates CSBP/p38 kinase from P450 inhibition for this series and furthermore achieves an increase in oral activity.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
|
pubmed:issn |
0960-894X
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|
pubmed:author |
pubmed-author:AdamsJ LJL,
pubmed-author:AyrtonAA,
pubmed-author:BoehmJ CJC,
pubmed-author:GallagherT FTF,
pubmed-author:GoryckiP DPD,
pubmed-author:GriswoldD EDE,
pubmed-author:HallRR,
pubmed-author:KassisSS,
pubmed-author:LeeJ CJC,
pubmed-author:SorensonMM,
pubmed-author:WebbE FEF
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|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
8
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3111-6
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|
pubmed:dateRevised |
2009-11-19
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|
pubmed:meshHeading |
pubmed-meshheading:9873686-Animals,
pubmed-meshheading:9873686-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9873686-Cytochrome P-450 Enzyme System,
pubmed-meshheading:9873686-Enzyme Inhibitors,
pubmed-meshheading:9873686-Humans,
pubmed-meshheading:9873686-Imidazoles,
pubmed-meshheading:9873686-Mice,
pubmed-meshheading:9873686-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9873686-Pyrimidines,
pubmed-meshheading:9873686-Rats,
pubmed-meshheading:9873686-Structure-Activity Relationship,
pubmed-meshheading:9873686-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
1998
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|
pubmed:articleTitle |
Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.
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pubmed:affiliation |
SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA.
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pubmed:publicationType |
Journal Article
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