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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
1999-1-26
|
| pubmed:abstractText |
Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2977-82
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9873658-Antineoplastic Agents,
pubmed-meshheading:9873658-Drug Design,
pubmed-meshheading:9873658-Drug Resistance, Multiple,
pubmed-meshheading:9873658-Humans,
pubmed-meshheading:9873658-P-Glycoprotein,
pubmed-meshheading:9873658-Paclitaxel,
pubmed-meshheading:9873658-Structure-Activity Relationship
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Synthesis and evaluation of artificial taxoids with antitumor and multi-drug resistance reversing activities.
|
| pubmed:affiliation |
Department of Chemistry, Tokyo Institute of Technology, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|