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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
20
|
| pubmed:dateCreated |
1999-2-2
|
| pubmed:abstractText |
A short and efficient synthesis of novel benzo[c]quinolizin-3-one derivatives is described. The synthesis is based on the tandem Mannich-Michael cyclization between 2-silyloxy-1,3-butadienes and a N-t-Boc iminium ion. The prepared derivatives are selective inhibitors of human steroid 5 alpha-reductase isoenzyme 1, thus having potential application as drugs for treatment of male pattern baldness and other DHT-dependent skin disorders.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2871-6
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9873639-5-alpha Reductase Inhibitors,
pubmed-meshheading:9873639-Alopecia,
pubmed-meshheading:9873639-Enzyme Inhibitors,
pubmed-meshheading:9873639-Humans,
pubmed-meshheading:9873639-Inhibitory Concentration 50,
pubmed-meshheading:9873639-Isoenzymes,
pubmed-meshheading:9873639-Male,
pubmed-meshheading:9873639-Prostate,
pubmed-meshheading:9873639-Quinolizines
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Synthesis of benzo[c]quinolizin-3-ones: selective non-steroidal inhibitors of steroid 5 alpha-reductase 1.
|
| pubmed:affiliation |
Dipartimento di Chimica Organica U. Schiff, CNR, Università di Firenze, Italy. guarna@chimorg.unifi.it
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|