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9873627
Source:
http://linkedlifedata.com/resource/pubmed/id/9873627
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53
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0014631
,
umls-concept:C0022634
,
umls-concept:C0167118
,
umls-concept:C0220781
,
umls-concept:C0243077
,
umls-concept:C0330390
,
umls-concept:C1707689
,
umls-concept:C1883254
,
umls-concept:C2003941
,
umls-concept:C2717970
pubmed:issue
19
pubmed:dateCreated
1999-2-2
pubmed:abstractText
The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of cruzain, a cysteine protease isolated from Trypanosoma cruzi, with an apparent second order inhibition rate constant of 330,000 sec-1M-1.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/AI35707
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases
,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Proteinase Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides
,
http://linkedlifedata.com/resource/pubmed/chemical/Ketones
,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/cruzain, Trypanosoma cruzi
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0960-894X
pubmed:author
pubmed-author:GonzálezF VFV
,
pubmed-author:HansellEE
,
pubmed-author:McKerrowJ HJH
,
pubmed-author:RoushW RWR
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2809-12
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9873627-Cysteine Endopeptidases
,
pubmed-meshheading:9873627-Cysteine Proteinase Inhibitors
,
pubmed-meshheading:9873627-Dipeptides
,
pubmed-meshheading:9873627-Drug Design
,
pubmed-meshheading:9873627-Ketones
,
pubmed-meshheading:9873627-Kinetics
,
pubmed-meshheading:9873627-Protozoan Proteins
,
pubmed-meshheading:9873627-Stereoisomerism
,
pubmed-meshheading:9873627-Structure-Activity Relationship
pubmed:year
1998
pubmed:articleTitle
Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain.
pubmed:affiliation
Department of Chemistry, University of Michigan, Ann Arbor 48109, USA.
pubmed:publicationType
Journal Article
,
Research Support, U.S. Gov't, P.H.S.
,
Research Support, Non-U.S. Gov't