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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
19
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pubmed:dateCreated |
1999-2-2
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|
pubmed:abstractText |
Replacement of the C-terminal carboxylic acid functionality of peptide inhibitors of hepatitis C virus (HCV) NS3 protease (complexed with NS4A peptide cofactor) by activated carbonyl groups does not produce any substantial increase in potency. These latter inhibitors also inhibit a variety of other serine and cysteine proteases whereas the carboxylic acids are specific. Norvaline was identified as a chemically stable replacement for the P1 residue of Ac-DDIVPC-OH which was also compatible with activated carbonyl functionalities.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BaileyMM,
pubmed-author:DézielRR,
pubmed-author:FazalGG,
pubmed-author:GorysVV,
pubmed-author:GouletSS,
pubmed-author:HalmosTT,
pubmed-author:LamarreDD,
pubmed-author:Llinàs-BrunetMM,
pubmed-author:MauriceRR,
pubmed-author:PoirierMM,
pubmed-author:PoupartM AMA,
pubmed-author:RancourtJJ,
pubmed-author:ThibeaultDD,
pubmed-author:WernicDD
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|
pubmed:issnType |
Print
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|
pubmed:day |
6
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2719-24
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|
pubmed:dateRevised |
2001-11-2
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|
pubmed:meshHeading |
|
|
pubmed:year |
1998
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|
pubmed:articleTitle |
Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.
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|
pubmed:affiliation |
Boehringer Ingelheim (Canada) Ltd, Bio-Méga Research Division, Laval, Québec, Canada.
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pubmed:publicationType |
Journal Article
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