9873608

Source:http://linkedlifedata.com/resource/pubmed/id/9873608

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0024432, umls-concept:C0025914, umls-concept:C0026809, umls-concept:C0028128, umls-concept:C0033268, umls-concept:C0205177, umls-concept:C0205250, umls-concept:C0205314, umls-concept:C0220781, umls-concept:C0679622, umls-concept:C0762434, umls-concept:C1707689, umls-concept:C1883254, umls-concept:C1999216
pubmed:issue	19
pubmed:dateCreated	1999-2-2
pubmed:abstractText	New derivatives with electron-withdrawing substituents at the C-2 position of 3-oxoolean-1-en-28-oic acid were synthesized. Among them, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) was 400 times more potent than previous compounds we have made as an inhibitor of production of nitric oxide induced by interferon-gamma in mouse macrophages (IC50, 0.4 nM). The potency of CDDO was similar to that of dexamethasone, although CDDO does not act through the glucocorticoid receptor.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II, http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Oleanolic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0960-894X
pubmed:author	pubmed-author:GribbleG WGW, pubmed-author:HondaTT, pubmed-author:RoundsB VBV, pubmed-author:SpornM BMB, pubmed-author:SunDD, pubmed-author:WangYY
pubmed:issnType	Print
pubmed:day	6
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2711-4
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:9873608-Animals, pubmed-meshheading:9873608-Cyclooxygenase 2, pubmed-meshheading:9873608-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:9873608-Cyclooxygenase Inhibitors, pubmed-meshheading:9873608-Dexamethasone, pubmed-meshheading:9873608-Drug Design, pubmed-meshheading:9873608-Enzyme Inhibitors, pubmed-meshheading:9873608-Glucocorticoids, pubmed-meshheading:9873608-Interferon-gamma, pubmed-meshheading:9873608-Isoenzymes, pubmed-meshheading:9873608-Macrophages, pubmed-meshheading:9873608-Mice, pubmed-meshheading:9873608-Nitric Oxide, pubmed-meshheading:9873608-Nitric Oxide Synthase, pubmed-meshheading:9873608-Nitric Oxide Synthase Type II, pubmed-meshheading:9873608-Oleanolic Acid, pubmed-meshheading:9873608-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:9873608-Structure-Activity Relationship
pubmed:year	1998
pubmed:articleTitle	Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages.
pubmed:affiliation	Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't