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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1999-2-2
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pubmed:abstractText |
The synthesis of several bioisosteric analogs based on the 3-OH-N1-phenylpiperazine dopamine D2 agonist template (i.e., 4) is described. The indolone (5) and 2-CF3-benzimidazole (13) were observed to have excellent affinity for the D2 receptor. Several D4 selective compounds were also identified. Molecular modeling studies and a putative bioactive conformation are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Drd3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Psychotropic Drugs,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D3,
http://linkedlifedata.com/resource/pubmed/chemical/phenylpiperazine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2675-80
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9873601-Animals,
pubmed-meshheading:9873601-Benzimidazoles,
pubmed-meshheading:9873601-Corpus Striatum,
pubmed-meshheading:9873601-Dopamine Agents,
pubmed-meshheading:9873601-Dopamine Agonists,
pubmed-meshheading:9873601-Indoles,
pubmed-meshheading:9873601-Kinetics,
pubmed-meshheading:9873601-Piperazines,
pubmed-meshheading:9873601-Psychotropic Drugs,
pubmed-meshheading:9873601-Rats,
pubmed-meshheading:9873601-Receptors, Dopamine D2,
pubmed-meshheading:9873601-Receptors, Dopamine D3,
pubmed-meshheading:9873601-Structure-Activity Relationship,
pubmed-meshheading:9873601-Templates, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.
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pubmed:affiliation |
Global Chemical Sciences, Wyeth-Ayerst Research Laboratory, Princeton, NJ 08543-8000, USA.
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pubmed:publicationType |
Journal Article
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