|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
19
|
|
pubmed:dateCreated |
1999-2-2
|
|
pubmed:abstractText |
A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC50S in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:BethellRR,
pubmed-author:BirdA JAJ,
pubmed-author:DowningSS,
pubmed-author:GreenD VDV,
pubmed-author:MadarSS,
pubmed-author:MiltonJJ,
pubmed-author:PriceC ECE,
pubmed-author:ScottGG,
pubmed-author:SlaterM JMJ,
pubmed-author:SpinksDD,
pubmed-author:StammersD KDK
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
6
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2623-8
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Biaryl acids: novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2.
|
|
pubmed:affiliation |
Department of Chemistry, GlaxoWellcome Medicines Research Center, Stevenage, Oxford.
|
|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|
