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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
18
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pubmed:dateCreated |
1999-2-2
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|
pubmed:abstractText |
5-(2-Pyridylsulfonyl)-2-thiazolamine (2) was effective both in mitomycin C (MMC)-induced thrombocytopenia and in an animal model of idiopathic thrombocytopenic purpura (ITP). It also suppressed the increase of autoantibodies against platelets in the ITP model and showed no blood toxicity. Chemical modification of 2 led to the discovery of more potent compounds against MMC-induced thrombocytopenia.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
22
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2473-8
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|
pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9873564-Animals,
pubmed-meshheading:9873564-Autoantibodies,
pubmed-meshheading:9873564-Blood Platelets,
pubmed-meshheading:9873564-Dapsone,
pubmed-meshheading:9873564-Disease Models, Animal,
pubmed-meshheading:9873564-Dose-Response Relationship, Drug,
pubmed-meshheading:9873564-Male,
pubmed-meshheading:9873564-Mice,
pubmed-meshheading:9873564-Mitomycin,
pubmed-meshheading:9873564-Models, Chemical,
pubmed-meshheading:9873564-Purpura, Thrombocytopenic, Idiopathic,
pubmed-meshheading:9873564-Pyridines,
pubmed-meshheading:9873564-Thiazoles,
pubmed-meshheading:9873564-Thrombocytopenia
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Synthesis and effects of novel thiazole derivatives against thrombocytopenia.
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|
pubmed:affiliation |
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
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pubmed:publicationType |
Journal Article
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