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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
18
|
| pubmed:dateCreated |
1999-2-2
|
| pubmed:abstractText |
The program DOCK was used to search for novel inhibitors for alpha-thrombin. Four among the top twelve best scoring compounds from the Cambridge Structural Data Base inhibited this enzyme, and three of them inhibited alpha-thrombin in a competitive mode. These molecules are expected to serve as general templates for structural elaboration in targeting diverse serine proteases for selective inhibition.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
22
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2463-6
|
| pubmed:dateRevised |
2002-11-1
|
| pubmed:meshHeading |
pubmed-meshheading:9873562-Binding Sites,
pubmed-meshheading:9873562-Databases, Factual,
pubmed-meshheading:9873562-Drug Design,
pubmed-meshheading:9873562-Models, Chemical,
pubmed-meshheading:9873562-Models, Molecular,
pubmed-meshheading:9873562-Protein Conformation,
pubmed-meshheading:9873562-Serine Proteinase Inhibitors,
pubmed-meshheading:9873562-Software,
pubmed-meshheading:9873562-Templates, Genetic,
pubmed-meshheading:9873562-Thrombin
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Templates for design of inhibitors for serine proteases: application of the program DOCK to the discovery of novel inhibitors for thrombin.
|
| pubmed:affiliation |
Department of Chemistry, Wayne State University, Detroit, MI 48202-3489, USA.
|
| pubmed:publicationType |
Journal Article
|