|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0020746,
umls-concept:C0220781,
umls-concept:C0280697,
umls-concept:C0348080,
umls-concept:C0439064,
umls-concept:C0439831,
umls-concept:C0443286,
umls-concept:C1366479,
umls-concept:C1510941,
umls-concept:C1883254,
umls-concept:C1999216,
umls-concept:C2348042,
umls-concept:C2698650
|
|
pubmed:issue |
17
|
|
pubmed:dateCreated |
1999-2-1
|
|
pubmed:abstractText |
Optimization of a 2-step reaction sequence was accomplished in 3-4 days, with over 200 different reaction conditions evaluated. Combinatorial arrays were performed using the optimized conditions to synthesize 590 new compounds which were tested for inhibition against N-His (D381E) ICE. Thirty-five compounds showed at least a tenfold improvement in activity compared to an initial standard.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2309-14
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9873533-Amino Acid Substitution,
pubmed-meshheading:9873533-Aspartic Acid,
pubmed-meshheading:9873533-Automation,
pubmed-meshheading:9873533-Caspase 1,
pubmed-meshheading:9873533-Cysteine Proteinase Inhibitors,
pubmed-meshheading:9873533-Drug Design,
pubmed-meshheading:9873533-Indicators and Reagents,
pubmed-meshheading:9873533-Ketones,
pubmed-meshheading:9873533-Kinetics,
pubmed-meshheading:9873533-Molecular Structure,
pubmed-meshheading:9873533-Structure-Activity Relationship
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Rapid optimization of an ICE inhibitor synthesis using multiple reaction conditions in a parallel array.
|
|
pubmed:affiliation |
Department of Chemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
