|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
17
|
|
pubmed:dateCreated |
1999-2-1
|
|
pubmed:abstractText |
A library of 2302 small molecule beta-turn mimetics was screened for inhibition of the alpha 4 beta 1 integrin-CS1 splice variant binding interaction. Preliminary data revealed several active ligands, and validation with purified material culminated in the identification of some of the first small molecule ligands (1, IC50 = 5 microM, and 2, IC50 = 8 microM) to be reported for this class of integrins.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2297-302
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9873531-Alternative Splicing,
pubmed-meshheading:9873531-Amino Acids,
pubmed-meshheading:9873531-Binding Sites,
pubmed-meshheading:9873531-Carboxylic Acids,
pubmed-meshheading:9873531-Databases as Topic,
pubmed-meshheading:9873531-Drug Design,
pubmed-meshheading:9873531-Integrin alpha4beta1,
pubmed-meshheading:9873531-Integrins,
pubmed-meshheading:9873531-Ligands,
pubmed-meshheading:9873531-Molecular Conformation,
pubmed-meshheading:9873531-Molecular Structure,
pubmed-meshheading:9873531-Receptors, Lymphocyte Homing,
pubmed-meshheading:9873531-Receptors, Very Late Antigen,
pubmed-meshheading:9873531-Reproducibility of Results,
pubmed-meshheading:9873531-Stereoisomerism,
pubmed-meshheading:9873531-Structure-Activity Relationship
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Novel inhibitors of alpha 4 beta 1 integrin receptor interactions through library synthesis and screening.
|
|
pubmed:affiliation |
Department of Chemistry, University of California, Berkeley 94720, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
