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9873524
Source:
http://linkedlifedata.com/resource/pubmed/id/9873524
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51
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0002482
,
umls-concept:C0041249
,
umls-concept:C0041942
,
umls-concept:C0243076
,
umls-concept:C1420563
,
umls-concept:C1424685
,
umls-concept:C1554184
,
umls-concept:C1705924
pubmed:issue
16
pubmed:dateCreated
1999-1-28
pubmed:abstractText
We report that a systematic modification of an NK1 receptor selective antagonist resulted in the identification of novel compounds, 4c and 4d, with high affinity for both NK1 and NK2 receptors.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amides
,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurokinin-1
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurokinin-2
,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0960-894X
pubmed:author
pubmed-author:CascieriM AMA
,
pubmed-author:MaCcossMM
,
pubmed-author:RECC
,
pubmed-author:SadowskiS JSJ
,
pubmed-author:ShahS KSK
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2259-62
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:9873524-Amides
,
pubmed-meshheading:9873524-Drug Design
,
pubmed-meshheading:9873524-Humans
,
pubmed-meshheading:9873524-Indicators and Reagents
,
pubmed-meshheading:9873524-Kinetics
,
pubmed-meshheading:9873524-Molecular Structure
,
pubmed-meshheading:9873524-Receptors, Neurokinin-1
,
pubmed-meshheading:9873524-Receptors, Neurokinin-2
,
pubmed-meshheading:9873524-Recombinant Proteins
,
pubmed-meshheading:9873524-Structure-Activity Relationship
,
pubmed-meshheading:9873524-Tryptophan
pubmed:year
1998
pubmed:articleTitle
L-tryptophan urea amides as NK1/NK2 dual antagonists.
pubmed:affiliation
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
pubmed:publicationType
Journal Article