|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
1999-1-28
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|
pubmed:abstractText |
A synthesis of the C-2-acetoxy-C-4-benzoate paclitaxel 2 is described. This analog has the substituents at C-2 and C-4 transposed. The key steps in the synthesis include the sequential use of Red-Al as reducing agent for the regioselective reduction of the C-2 benzoate and the C-4 acetoxy within the baccatin core. Iso-paclitaxel 2 was considerably less potent than paclitaxel in tubulin polymerization and in vitro cytotoxicity assays.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
18
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2227-30
|
|
pubmed:dateRevised |
2003-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:9873518-Animals,
pubmed-meshheading:9873518-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9873518-Cell Survival,
pubmed-meshheading:9873518-Drug Design,
pubmed-meshheading:9873518-Indicators and Reagents,
pubmed-meshheading:9873518-Molecular Conformation,
pubmed-meshheading:9873518-Molecular Structure,
pubmed-meshheading:9873518-Paclitaxel,
pubmed-meshheading:9873518-Structure-Activity Relationship,
pubmed-meshheading:9873518-Tubulin
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Synthesis of a paclitaxel isomer: C-2-acetoxy-C-4-benzoate paclitaxel.
|
|
pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA.
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|
pubmed:publicationType |
Journal Article
|
