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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1999-1-28
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pubmed:abstractText |
A series of mechanism-based inhibitors of phospholipase A2 (SIBLINKS) were synthesized. These new SIBLINKS are phospholipid analogues that contain a para-substituted phenyl 3,3-dimethylglutaryl group in the place of the sn-2 acyl chain. The effect of the phenyl leaving group on inhibitory activity was studied by varying the electron-withdrawing ability of the para-substituted group. A strong correlation was observed between the leaving group potential of the suicide inhibitor and the inhibitory activity of the derivative toward cobra venom phospholipase A2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2129-32
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9873499-Animals,
pubmed-meshheading:9873499-Cobra,
pubmed-meshheading:9873499-Cobra Venoms,
pubmed-meshheading:9873499-Drug Design,
pubmed-meshheading:9873499-Enzyme Inhibitors,
pubmed-meshheading:9873499-Kinetics,
pubmed-meshheading:9873499-Molecular Structure,
pubmed-meshheading:9873499-Phenols,
pubmed-meshheading:9873499-Phospholipases A,
pubmed-meshheading:9873499-Phospholipases A2,
pubmed-meshheading:9873499-Phospholipids,
pubmed-meshheading:9873499-Structure-Activity Relationship
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pubmed:year |
1998
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pubmed:articleTitle |
The structure-activity relationships of a series of suicide inhibitors of phospholipase A2.
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pubmed:affiliation |
La Jolla Pharmaceutical Co., San Diego, CA 92121, USA.
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pubmed:publicationType |
Journal Article
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