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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
1999-1-28
|
| pubmed:abstractText |
The wide ranging marine sponge Hyrtios erecta is the source of the spongistatins, a new class of macrocyclic lactone antineoplastic agents. Continuation of a detailed investigation of cancer cell growth inhibitory (P388 lymphocytic leukemia) fractions (trace) from H. erecta has revealed the presence (10(-5) to 10(-7)% yield) of cytotoxic pentacyclic sesterterpenes. Employing P388 leukemia and human tumor cell line-guided bioassay techniques, two new moderate inhibitors of cancer cells were isolated and named sesterstatins 4 (1a, P388 ED50 4.9 micrograms/mL) and 5 (1b, DU-145 prostate GI50 1.9 micrograms/mL). Similar to other sesterterpenes, sesterstatin 5 inhibited growth of a Gram-positive bacterium. High field (500 MHz) 2-D NMR techniques were primarily employed for initial structural assignments, and structural assignments were confirmed by X-ray crystal structure determination of sesterstatin 4 (1a) and 5 (1b).
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
18
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2093-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9873492-Animals,
pubmed-meshheading:9873492-Anti-Bacterial Agents,
pubmed-meshheading:9873492-Antineoplastic Agents,
pubmed-meshheading:9873492-Cell Division,
pubmed-meshheading:9873492-Cell Survival,
pubmed-meshheading:9873492-Gram-Positive Bacteria,
pubmed-meshheading:9873492-Humans,
pubmed-meshheading:9873492-Indian Ocean Islands,
pubmed-meshheading:9873492-Leukemia P388,
pubmed-meshheading:9873492-Male,
pubmed-meshheading:9873492-Mice,
pubmed-meshheading:9873492-Microbial Sensitivity Tests,
pubmed-meshheading:9873492-Models, Molecular,
pubmed-meshheading:9873492-Molecular Conformation,
pubmed-meshheading:9873492-Molecular Structure,
pubmed-meshheading:9873492-Porifera,
pubmed-meshheading:9873492-Structure-Activity Relationship,
pubmed-meshheading:9873492-Terpenes,
pubmed-meshheading:9873492-Tumor Cells, Cultured
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
|
| pubmed:affiliation |
Cancer Research Institute, Arizona State University, Tempe 85287-2404, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|