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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1999-1-28
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pubmed:abstractText |
A series of succinate-derived hydroxamic acids incorporating a macrocyclic ring were designed, synthesized, and evaluated as inhibitors of matrix metalloproteinases. The inhibitors were designed based on the published X-ray crystal structure of batimastat (1) complexed with human neutrophil collagenase (MMP-8). The synthesized compounds were shown to inhibit selected MMPs in vitro with low nanomolar potency.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AlbertD HDH,
pubmed-author:CurtinM LML,
pubmed-author:DavidsenS KSK,
pubmed-author:GarlandR BRB,
pubmed-author:HeymanH RHR,
pubmed-author:HolmsJ HJH,
pubmed-author:HutchinsCC,
pubmed-author:MagocT JTJ,
pubmed-author:MarcotteP APA,
pubmed-author:MorganD WDW,
pubmed-author:NagyI BIB,
pubmed-author:OOIS KSK,
pubmed-author:SteinmanD HDH,
pubmed-author:SummersJ BJB
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2087-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9873491-Collagenases,
pubmed-meshheading:9873491-Crystallography, X-Ray,
pubmed-meshheading:9873491-Drug Design,
pubmed-meshheading:9873491-Humans,
pubmed-meshheading:9873491-Hydroxamic Acids,
pubmed-meshheading:9873491-Indicators and Reagents,
pubmed-meshheading:9873491-Kinetics,
pubmed-meshheading:9873491-Matrix Metalloproteinase 8,
pubmed-meshheading:9873491-Models, Molecular,
pubmed-meshheading:9873491-Phenylalanine,
pubmed-meshheading:9873491-Protease Inhibitors,
pubmed-meshheading:9873491-Structure-Activity Relationship,
pubmed-meshheading:9873491-Succinates,
pubmed-meshheading:9873491-Thiophenes
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pubmed:year |
1998
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pubmed:articleTitle |
The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors.
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pubmed:affiliation |
Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, USA.
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pubmed:publicationType |
Journal Article
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