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rdf:type |
|
|
lifeskim:mentions |
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|
pubmed:issue |
15
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|
pubmed:dateCreated |
1999-2-2
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|
pubmed:abstractText |
The chloro-, bromo-, and iodo-derivatives 2-4 of the antimitotic drug cryptophycin 1 were synthesized by opening the epoxide ring. The biological activities of the compounds were tested in an in vitro microtubule assembly and a cell proliferation assay. The chloro-derivative 2 showed lower activity in the tubulin assay compared to 3 and 4, but they all showed similar inhibition in the proliferation assay.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
4
|
|
pubmed:volume |
8
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1959-62
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9873466-Antineoplastic Agents,
pubmed-meshheading:9873466-Depsipeptides,
pubmed-meshheading:9873466-Half-Life,
pubmed-meshheading:9873466-Indans,
pubmed-meshheading:9873466-Melanoma, Experimental,
pubmed-meshheading:9873466-Microtubules,
pubmed-meshheading:9873466-Mitosis,
pubmed-meshheading:9873466-Peptides, Cyclic,
pubmed-meshheading:9873466-Structure-Activity Relationship,
pubmed-meshheading:9873466-Tubulin,
pubmed-meshheading:9873466-Tumor Cells, Cultured
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Halohydrin analogues of cryptophycin 1: synthesis and biological activity.
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|
pubmed:affiliation |
Department of Medicinal Chemistry, University of Kansas, Lawrence 66045, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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