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pubmed-article:9873455pubmed:abstractTextThe synthesis and in vitro optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives discovered by a random screening process, are described. FR180102 (7f), having a 3-acetamido-2,6-dichlorobenzyl moiety, was found to have extremely potent activity against H. pylori and no effect against a series of common Gram-positive and Gram-negative bacteria.lld:pubmed
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pubmed-article:9873455pubmed:articleTitleDiscovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity.lld:pubmed
pubmed-article:9873455pubmed:affiliationMedicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan.lld:pubmed
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