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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
14
|
| pubmed:dateCreated |
1999-2-4
|
| pubmed:abstractText |
The synthesis and in vitro optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives discovered by a random screening process, are described. FR180102 (7f), having a 3-acetamido-2,6-dichlorobenzyl moiety, was found to have extremely potent activity against H. pylori and no effect against a series of common Gram-positive and Gram-negative bacteria.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
21
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1897-902
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9873455-Acetamides,
pubmed-meshheading:9873455-Animals,
pubmed-meshheading:9873455-Anti-Bacterial Agents,
pubmed-meshheading:9873455-Helicobacter pylori,
pubmed-meshheading:9873455-Isoquinolines,
pubmed-meshheading:9873455-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9873455-Mice,
pubmed-meshheading:9873455-Microbial Sensitivity Tests,
pubmed-meshheading:9873455-Structure-Activity Relationship
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity.
|
| pubmed:affiliation |
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan.
|
| pubmed:publicationType |
Journal Article
|