|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
1999-1-29
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|
pubmed:abstractText |
The synthesis and purinergic receptor binding of novel adenosine A3 ligands is described. Many selective A3 receptor agonists e.g. N-(3-iodobenzyl)adenosine-5'-methyluronamide (IB-MECA) contain a 4'-ribosylalkylamide moiety. We found that this amide and other 4'-functional groups could be replaced with an isosteric isoxazole, and the target molecules retained potent binding to the recombinant human A3 receptor.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1767-70
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9873431-Adenosine,
pubmed-meshheading:9873431-Animals,
pubmed-meshheading:9873431-Cell Line,
pubmed-meshheading:9873431-Humans,
pubmed-meshheading:9873431-Isoxazoles,
pubmed-meshheading:9873431-Ligands,
pubmed-meshheading:9873431-Rats,
pubmed-meshheading:9873431-Receptors, Purinergic P1,
pubmed-meshheading:9873431-Recombinant Proteins,
pubmed-meshheading:9873431-Structure-Activity Relationship
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.
|
|
pubmed:affiliation |
Novo Nordisk A/S, Måløv, Denmark.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
