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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1999-2-1
|
| pubmed:abstractText |
A number of lipophilic platinum(II) complexes of the general structures cis-[Pt(LA)2Cl2] and [Pt(LD)Cl2] were synthesised. Long chain amines (LA) and diamines (LD), prepared from lipidic amino acids, were used as ligands. The in vitro cytotoxicity of the complexes was evaluated against four cell lines (P388, NSCLC-N6, E39, M96). cis-Dichloro-bis(2-aminohexadecanol)platinum(II) was the most active against P388, NSCLC-N6 and E39 (IC50: 11 micrograms/ml, 25 micrograms/ml, 31 micrograms/ml), while dichloro(1,3-heptadecanediamine)platinum(II) presented the highest activity against M96 (IC50: 13 micrograms/ml).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
16
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1525-30
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9873383-Antineoplastic Agents,
pubmed-meshheading:9873383-Drug Screening Assays, Antitumor,
pubmed-meshheading:9873383-Humans,
pubmed-meshheading:9873383-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9873383-Organoplatinum Compounds,
pubmed-meshheading:9873383-Spectrophotometry, Infrared,
pubmed-meshheading:9873383-Tumor Cells, Cultured
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Synthesis and in vitro cytotoxicity of lipophilic platinum(II) complexes.
|
| pubmed:affiliation |
Department of Chemistry, University of Athens, Greece. gkokotos@atlas.uoa.gr
|
| pubmed:publicationType |
Journal Article
|