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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
12
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pubmed:dateCreated |
1999-2-1
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pubmed:abstractText |
A series of potent specific HIV-1 RT inhibitory compounds is described. The compounds are urea analogs of PETT (PhenylEthylThiazoleThiourea) derivatives and the series includes derivatives with an ethyl linker (1-6) and conformationally restricted analogs (7-13). The antiviral activity is determined both at the RT level and in cell culture on both native and mutant forms of HIV-1. Many compounds display activity in the nM range against wt-RT.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jun
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|
pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
16
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1511-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9873380-Anti-HIV Agents,
pubmed-meshheading:9873380-Blood Proteins,
pubmed-meshheading:9873380-Cell Line,
pubmed-meshheading:9873380-HIV-1,
pubmed-meshheading:9873380-Humans,
pubmed-meshheading:9873380-Microbial Sensitivity Tests,
pubmed-meshheading:9873380-Protein Binding,
pubmed-meshheading:9873380-Reverse Transcriptase Inhibitors,
pubmed-meshheading:9873380-Structure-Activity Relationship,
pubmed-meshheading:9873380-Thiazoles,
pubmed-meshheading:9873380-Triazoles
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
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pubmed:affiliation |
Medivir AB, Huddinge, Sweden. christer.sahlberg@medivir.se
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pubmed:publicationType |
Journal Article
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