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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1999-2-1
|
| pubmed:abstractText |
During a chemistry program aimed at finding a novel analogue of pentaquine with improved in vivo activity, a number of hypotheses concerning the way this drug acts in the chicken were investigated. Consideration of the products of monoamine oxidase metabolism of pentaquine suggested that pentaquine aldehyde is the likely active metabolite. Although isolation of this unstable compound was not possible, oxime and cyclic acetal and ketal derivatives were obtained and shown to possess in vitro anticoccidial activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
16
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1487-92
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9873375-Aminoquinolines,
pubmed-meshheading:9873375-Animals,
pubmed-meshheading:9873375-Cattle,
pubmed-meshheading:9873375-Cells, Cultured,
pubmed-meshheading:9873375-Chickens,
pubmed-meshheading:9873375-Coccidiostats,
pubmed-meshheading:9873375-Monoamine Oxidase,
pubmed-meshheading:9873375-Monoamine Oxidase Inhibitors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
8-Aminoquinolines as anticoccidials--II.
|
| pubmed:affiliation |
Animal Health Discovery, Pfizer Central Research, Sandwich, Kent, U.K.
|
| pubmed:publicationType |
Journal Article
|