| pubmed-article:9873223 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9873223 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9873223 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9873223 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:9873223 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:9873223 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:9873223 | lifeskim:mentions | umls-concept:C0598934 | lld:lifeskim |
| pubmed-article:9873223 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9873223 | pubmed:dateCreated | 1999-3-5 | lld:pubmed |
| pubmed-article:9873223 | pubmed:abstractText | Expression of interleukin-8 (IL-8) by human melanoma cells correlates with their metastatic potential in vivo. Moreover, UVB irradiation of primary cutaneous melanoma induces IL-8 mRNA and protein production and increases both tumor growth and metastasis in nude mice. Although IL-8 has been shown to be an angiogenic factor, the biological consequences of increased IL-8 production by melanoma cells and the role of IL-8 in the metastatic process remains unclear. The purpose of this review is to determine the role of IL-8 in tumor growth and metastasis of human melanoma. Transfection of nonmetastatic and IL-8-negative melanoma cells with the IL-8 gene rendered them highly tumorigenic and increased their metastatic potential in nude mice. The IL-8-transfected cells displayed upregulation of MMP-2 expression and activity and increased invasiveness through Matrigel-coated filters. Activation of MMP-2 by IL-8 can enhance the invasion of host stroma by the tumor cells and increase angiogenesis and, hence, metastasis. In addition to UVB, IL-8 can also be upregulated by hypoxia conditions, suggesting that the environment plays a major role in regulating IL-8 expression and metastasis. The studies summarized in this review suggest that in melanoma, IL-8 may serve as the angiogenic factor distinguishing benign from malignant cells. | lld:pubmed |
| pubmed-article:9873223 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9873223 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9873223 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9873223 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9873223 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9873223 | pubmed:issn | 1015-2008 | lld:pubmed |
| pubmed-article:9873223 | pubmed:author | pubmed-author:Bar-EliMM | lld:pubmed |
| pubmed-article:9873223 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9873223 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:9873223 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9873223 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9873223 | pubmed:pagination | 12-8 | lld:pubmed |
| pubmed-article:9873223 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9873223 | pubmed:meshHeading | pubmed-meshheading:9873223-... | lld:pubmed |
| pubmed-article:9873223 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9873223 | pubmed:articleTitle | Role of interleukin-8 in tumor growth and metastasis of human melanoma. | lld:pubmed |
| pubmed-article:9873223 | pubmed:affiliation | Department of Cell Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Tex. 77030, USA. mbareli@notes.mdacc.tmc.edu | lld:pubmed |
| pubmed-article:9873223 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9873223 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9873223 | pubmed:publicationType | Review | lld:pubmed |
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