|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1999-3-11
|
|
pubmed:abstractText |
The asymmetric synthesis of (S)-Boc-N-methyl-p-benzoyl-phenylalanine was performed by alkylation of sultam Boc-sarcosinate. The levorotatory sultam led to (S)-Boc-N-methyl amino acids with high optical purity. This photoreactive amino acid was incorporated into the sequence of a Substance P peptide antagonist. Comparison of the affinity and antagonistic properties of Biotinyl-apa-[D-Pro9, MePhe(pBz)10, Trp11]SP for human tachykinin NK-1 receptor demonstrated that this photoreactive antagonist should be a suitable tool for photolabelling studies.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
2
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1369-74
|
|
pubmed:dateRevised |
2005-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:9871768-Alkylation,
pubmed-meshheading:9871768-Animals,
pubmed-meshheading:9871768-Biotin,
pubmed-meshheading:9871768-CHO Cells,
pubmed-meshheading:9871768-Cricetinae,
pubmed-meshheading:9871768-Cyclic AMP,
pubmed-meshheading:9871768-Humans,
pubmed-meshheading:9871768-Molecular Conformation,
pubmed-meshheading:9871768-Phenylalanine,
pubmed-meshheading:9871768-Photochemistry,
pubmed-meshheading:9871768-Receptors, Neurokinin-1,
pubmed-meshheading:9871768-Receptors, Neurokinin-2,
pubmed-meshheading:9871768-Structure-Activity Relationship,
pubmed-meshheading:9871768-Substance P
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Asymmetric synthesis of Boc-N-methyl-p-benzoyl-phenylalanine. Preparation of a photoreactive antagonist of substance P.
|
|
pubmed:affiliation |
Laboratoire de Chimie Organique Biologique associé au CNRS, Université P. et M. Curie, UMR 7613, Paris, France.
|
|
pubmed:publicationType |
Journal Article
|
