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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1999-3-11
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pubmed:abstractText |
Matrix metalloproteinase inhibitors of general formula (1) were synthesised by a route involving an Ireland-Claisen rearrangement which enables systematic modification of the substituent alpha to the hydroxamic acid. An analogue (12c) possessing an alpha-cyclopentyl group is a potent broad spectrum inhibitor that displays high and sustained blood levels following oral dosing in both the rat and marmoset ex-vivo bioassays. This compound and analogues are also potent inhibitors of TNF alpha release.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BeckettR PRP,
pubmed-author:BellamyC LCL,
pubmed-author:CorkillD JDJ,
pubmed-author:CossinsJJ,
pubmed-author:CourtneyP FPF,
pubmed-author:DavidsonA HAH,
pubmed-author:DaviesS JSJ,
pubmed-author:DrummondA HAH,
pubmed-author:HelfrichKK,
pubmed-author:LewisC NCN,
pubmed-author:ManganMM,
pubmed-author:MartinF MFM,
pubmed-author:MillerKK,
pubmed-author:NayeePP,
pubmed-author:PrattL MLM,
pubmed-author:RickettsM LML,
pubmed-author:ThomasWW,
pubmed-author:ToddR SRS,
pubmed-author:WhittakerMM
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1359-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9871766-Administration, Oral,
pubmed-meshheading:9871766-Animals,
pubmed-meshheading:9871766-Biological Availability,
pubmed-meshheading:9871766-Callithrix,
pubmed-meshheading:9871766-Depression, Chemical,
pubmed-meshheading:9871766-Hydroxamic Acids,
pubmed-meshheading:9871766-Lipopolysaccharides,
pubmed-meshheading:9871766-Metalloendopeptidases,
pubmed-meshheading:9871766-Protease Inhibitors,
pubmed-meshheading:9871766-Rats,
pubmed-meshheading:9871766-Tumor Necrosis Factor-alpha
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pubmed:year |
1998
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pubmed:articleTitle |
The synthesis of novel matrix metalloproteinase inhibitors employing the Ireland-Claisen rearrangement.
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pubmed:affiliation |
British Biotech Pharmaceuticals Limited, Cowley, Oxford.
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pubmed:publicationType |
Journal Article
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