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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
11
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pubmed:dateCreated |
1999-3-11
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pubmed:abstractText |
Comparative molecular field analysis (CoMFA), a three-dimensional quantitative structure-activity relationship (3D-QSAR) paradigm was used to study the correlation between the physicochemical properties and the in vitro bioactivities of ginkgolide analogues. The correlation derived from CoMFA analysis has a good predictive capability. Based on the result of CoMFA analysis, we designed some compounds. Pharmacological assay indicated that three of these new designed compounds are 2 and 4 times more potent than that of ginkgolides.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1291-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
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pubmed:year |
1998
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pubmed:articleTitle |
A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis.
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pubmed:affiliation |
Shanghai Institute of Material Medica, Chinese Academy of Sciences, P.R. China.
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pubmed:publicationType |
Journal Article
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