9871746

Source:http://linkedlifedata.com/resource/pubmed/id/9871746

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0205198, umls-concept:C0220781, umls-concept:C0279516, umls-concept:C0332464, umls-concept:C1883254, umls-concept:C2827424
pubmed:issue	10
pubmed:dateCreated	1999-1-25
pubmed:abstractText	The enhanced stability of the carbacephem nucleus over the corresponding cephalosporin nucleus has allowed the synthesis of 7-arylglycyl-3-trifluoromethyl-carbacephems. These unique carbacephems possess broad spectrum activity and high stability to both plasmid and chromosomally mediated beta-lactamases.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cefaclor, http://linkedlifedata.com/resource/pubmed/chemical/Cephalosporins, http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents, http://linkedlifedata.com/resource/pubmed/chemical/beta-Lactamases
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0960-894X
pubmed:author	pubmed-author:CookG KGK, pubmed-author:HornbackW JWJ, pubmed-author:McDonaldJ HJH3rd, pubmed-author:MunroeJ EJE, pubmed-author:SnyderN JNJ
pubmed:issnType	Print
pubmed:day	19
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1261-6
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:9871746-Bacteria, pubmed-meshheading:9871746-Cefaclor, pubmed-meshheading:9871746-Cephalosporins, pubmed-meshheading:9871746-Chromosomes, Bacterial, pubmed-meshheading:9871746-Drug Design, pubmed-meshheading:9871746-Enterobacter, pubmed-meshheading:9871746-Escherichia coli, pubmed-meshheading:9871746-Gram-Negative Bacteria, pubmed-meshheading:9871746-Haemophilus influenzae, pubmed-meshheading:9871746-Indicators and Reagents, pubmed-meshheading:9871746-Klebsiella pneumoniae, pubmed-meshheading:9871746-Microbial Sensitivity Tests, pubmed-meshheading:9871746-Molecular Structure, pubmed-meshheading:9871746-Plasmids, pubmed-meshheading:9871746-Staphylococcus, pubmed-meshheading:9871746-Streptococcus, pubmed-meshheading:9871746-Structure-Activity Relationship, pubmed-meshheading:9871746-beta-Lactamases
pubmed:year	1998
pubmed:articleTitle	3-trifluoromethylcarbacephems: synthesis of broad spectrum antibacterial compounds.
pubmed:affiliation	Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
pubmed:publicationType	Journal Article, Comparative Study