9871729

Source:http://linkedlifedata.com/resource/pubmed/id/9871729

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003209, umls-concept:C0007935, umls-concept:C0220781, umls-concept:C0243072, umls-concept:C0441655, umls-concept:C1515999, umls-concept:C1883254
pubmed:issue	10
pubmed:dateCreated	1999-1-25
pubmed:abstractText	Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Only four compounds (4-7) inhibited cyclo-oxygenase-2 activity. The majority of these samples showed anti-inflammatory effects in the mouse air pouch model.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents..., http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate 5-Lipoxygenase, http://linkedlifedata.com/resource/pubmed/chemical/Chalcone, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene B4, http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Propiophenones, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0960-894X
pubmed:author	pubmed-author:AlcarazM JMJ, pubmed-author:CharrisJ EJE, pubmed-author:DomínguezJ NJN, pubmed-author:FerrándizM LML, pubmed-author:HerenciaFF, pubmed-author:LoboG MGM, pubmed-author:UbedaAA
pubmed:issnType	Print
pubmed:day	19
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1169-74
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:9871729-Animals, pubmed-meshheading:9871729-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:9871729-Arachidonate 5-Lipoxygenase, pubmed-meshheading:9871729-Chalcone, pubmed-meshheading:9871729-Cyclooxygenase 2, pubmed-meshheading:9871729-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:9871729-Cyclooxygenase Inhibitors, pubmed-meshheading:9871729-Drug Design, pubmed-meshheading:9871729-Humans, pubmed-meshheading:9871729-Isoenzymes, pubmed-meshheading:9871729-Leukotriene B4, pubmed-meshheading:9871729-Lipoxygenase Inhibitors, pubmed-meshheading:9871729-Membrane Proteins, pubmed-meshheading:9871729-Mice, pubmed-meshheading:9871729-Molecular Structure, pubmed-meshheading:9871729-Neutrophils, pubmed-meshheading:9871729-Propiophenones, pubmed-meshheading:9871729-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:9871729-Structure-Activity Relationship
pubmed:year	1998
pubmed:articleTitle	Synthesis and anti-inflammatory activity of chalcone derivatives.
pubmed:affiliation	Departamento de Farmacología, Universidad de Valencia, Spain.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't