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rdf:type |
|
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lifeskim:mentions |
|
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pubmed:issue |
10
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|
pubmed:dateCreated |
1999-1-25
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pubmed:abstractText |
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity. Its pharmacological properties as a neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and were compared to those of Neuronorm and MEN10627.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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|
pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
19
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|
pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1153-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9871726-Alanine,
pubmed-meshheading:9871726-Amino Acid Sequence,
pubmed-meshheading:9871726-Animals,
pubmed-meshheading:9871726-Male,
pubmed-meshheading:9871726-Models, Molecular,
pubmed-meshheading:9871726-Molecular Structure,
pubmed-meshheading:9871726-Peptides, Cyclic,
pubmed-meshheading:9871726-Protein Conformation,
pubmed-meshheading:9871726-Rats,
pubmed-meshheading:9871726-Receptors, Neurokinin-2,
pubmed-meshheading:9871726-Structure-Activity Relationship,
pubmed-meshheading:9871726-Vas Deferens
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.
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pubmed:affiliation |
Centro Interuniveristario di Ricerca su Peptidi Bioattivi, Università di Napoli Federico II, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study
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