|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1999-1-25
|
|
pubmed:abstractText |
A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'- trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1051-6
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9871706-Antineoplastic Agents,
pubmed-meshheading:9871706-Cell Cycle,
pubmed-meshheading:9871706-Cell Division,
pubmed-meshheading:9871706-Cell Survival,
pubmed-meshheading:9871706-Chalcone,
pubmed-meshheading:9871706-Crystallography, X-Ray,
pubmed-meshheading:9871706-Drug Design,
pubmed-meshheading:9871706-Humans,
pubmed-meshheading:9871706-K562 Cells,
pubmed-meshheading:9871706-Models, Molecular,
pubmed-meshheading:9871706-Molecular Conformation,
pubmed-meshheading:9871706-Molecular Structure,
pubmed-meshheading:9871706-Structure-Activity Relationship
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Potent antimitotic and cell growth inhibitory properties of substituted chalcones.
|
|
pubmed:affiliation |
Dept. of Chemistry, University of Manchester Institute of Science and Technology, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
