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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-1-25
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pubmed:abstractText |
The structure-activity relationship study of one of recently described aromatase inhibitors, compound 1 (MR20814), allowed us to design some related derivatives as potential new inhibitors. Among those we synthesized, chlorophenylpyridylmethylenetetrahydroindolizinone 5 (MR20492) exhibited in vitro a ten-fold higher inhibition of the enzyme (IC50 = 0.2 +/- 0.0 microM and Ki = 10.3 +/- 3.3 nM).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1041-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9871704-Aromatase Inhibitors,
pubmed-meshheading:9871704-Drug Design,
pubmed-meshheading:9871704-Enzyme Inhibitors,
pubmed-meshheading:9871704-Fadrozole,
pubmed-meshheading:9871704-Female,
pubmed-meshheading:9871704-Humans,
pubmed-meshheading:9871704-Indicators and Reagents,
pubmed-meshheading:9871704-Indolizines,
pubmed-meshheading:9871704-Microsomes,
pubmed-meshheading:9871704-Placenta,
pubmed-meshheading:9871704-Pregnancy,
pubmed-meshheading:9871704-Pyridines,
pubmed-meshheading:9871704-Structure-Activity Relationship,
pubmed-meshheading:9871704-Triazoles
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pubmed:year |
1998
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pubmed:articleTitle |
Design and synthesis of a new type of non steroidal human aromatase inhibitors.
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pubmed:affiliation |
Centre d'Etudes et de Recherche sur le Médicament de Normandie, Laboratoire de Pharmacochimie, Caen, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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