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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-1-25
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pubmed:abstractText |
The first structure-activity relationships of the anthelmintic cyclooctadepsipeptide PF1022A have been established via a systematic exchange of the leucine residues by a series of related N-alkylated amino acids. The data presented strongly suggest that (L)-N-methyl-leucine is crucial for high in vivo activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1035-40
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9871703-Alkylation,
pubmed-meshheading:9871703-Amino Acids,
pubmed-meshheading:9871703-Animals,
pubmed-meshheading:9871703-Anthelmintics,
pubmed-meshheading:9871703-Depsipeptides,
pubmed-meshheading:9871703-Drug Design,
pubmed-meshheading:9871703-Feces,
pubmed-meshheading:9871703-Haemonchiasis,
pubmed-meshheading:9871703-Haemonchus,
pubmed-meshheading:9871703-Leucine,
pubmed-meshheading:9871703-Molecular Structure,
pubmed-meshheading:9871703-Parasite Egg Count,
pubmed-meshheading:9871703-Peptides, Cyclic,
pubmed-meshheading:9871703-Protein Conformation,
pubmed-meshheading:9871703-Sheep,
pubmed-meshheading:9871703-Structure-Activity Relationship
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pubmed:year |
1998
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pubmed:articleTitle |
PF1022A--a novel anthelmintic cyclooctadepsipeptide. Modification and exchange of the N-methyl leucine residues.
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pubmed:affiliation |
Bayer AG, Leverkusen, Germany. JUERGEN SCHERKENBECK.JS@bayer-ag.de
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pubmed:publicationType |
Journal Article
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