|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0031640,
umls-concept:C0205314,
umls-concept:C0205549,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0243077,
umls-concept:C0679622,
umls-concept:C1149866,
umls-concept:C1412691,
umls-concept:C1533691,
umls-concept:C1849508,
umls-concept:C1883254
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1999-2-4
|
|
pubmed:abstractText |
This communication describes the synthesis and in vitro evaluation of a novel potent series of phosphodiesterase type (IV) (PDE IV) inhibitors. Several of the quaternary substituted lactams presented possess low nanomolar IC50's for PDE IV inhibition.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
399-404
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Quaternary substituted PDE IV inhibitors II: the synthesis and in vitro evaluation of a novel series of gamma-lactams.
|
|
pubmed:affiliation |
Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426, USA.
|
|
pubmed:publicationType |
Journal Article
|
