rdf:type |
|
lifeskim:mentions |
umls-concept:C0026249,
umls-concept:C0205409,
umls-concept:C0212192,
umls-concept:C0242724,
umls-concept:C0330862,
umls-concept:C0441655,
umls-concept:C0600686,
umls-concept:C1514485,
umls-concept:C1519477,
umls-concept:C1879547,
umls-concept:C2697903
|
pubmed:issue |
3
|
pubmed:dateCreated |
1999-2-1
|
pubmed:abstractText |
We investigated the immunomodulatory effects of antiallergic constituents from Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO, on splenocyte proliferation in mice. Thunberginol A and hydrangenol significantly suppressed T lymphocyte proliferation induced by concanavalin A. Thunberginol A also suppressed B lymphocyte proliferation induced by lipopolysaccharide, but other constituents induced significant increases. These inhibitory effects of thunberginol A on splenocyte proliferation seemed to contribute to the suppressive effect on type IV allergy.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0960-894X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
3
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
215-20
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9871657-Adjuvants, Immunologic,
pubmed-meshheading:9871657-Animals,
pubmed-meshheading:9871657-Anti-Allergic Agents,
pubmed-meshheading:9871657-Cell Division,
pubmed-meshheading:9871657-Coumarins,
pubmed-meshheading:9871657-Female,
pubmed-meshheading:9871657-Isocoumarins,
pubmed-meshheading:9871657-Mice,
pubmed-meshheading:9871657-Mice, Inbred C57BL,
pubmed-meshheading:9871657-Mitogens,
pubmed-meshheading:9871657-Plant Leaves,
pubmed-meshheading:9871657-Plants, Medicinal,
pubmed-meshheading:9871657-Spleen,
pubmed-meshheading:9871657-T-Lymphocytes
|
pubmed:year |
1998
|
pubmed:articleTitle |
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
|
pubmed:affiliation |
Kyoto Pharmaceutical University, Japan.
|
pubmed:publicationType |
Journal Article,
In Vitro
|