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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-1-14
|
| pubmed:abstractText |
A number of novel propargylic sulfone conjugates 3 and 4 with intercalating moieties were synthesized and evaluated for DNA cleavage activity through nucleic base alkylation. A remarkable enhancement in DNA cleaving potency was observed with those conjugates 3 possessing a suitable spacer, a right attachment point at the aromatic ring, and a good intercalator.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
169-74
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9871648-Alkynes,
pubmed-meshheading:9871648-Bacteriophage phi X 174,
pubmed-meshheading:9871648-DNA, Viral,
pubmed-meshheading:9871648-Electrophoresis, Agar Gel,
pubmed-meshheading:9871648-Hydrolysis,
pubmed-meshheading:9871648-Intercalating Agents,
pubmed-meshheading:9871648-Isatin
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Remarkable tethering effect on DNA cleavage of propargylic sulfone conjugates with intercalating moieties.
|
| pubmed:affiliation |
Department of Chemistry, Hong Kong University of Science and Technology, Kowloon, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|