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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-1-14
|
| pubmed:abstractText |
In order to develop new specific glutamate analogues at metabotropic glutamate receptors, Diels-Alder, 1-4 ionic and radical reactions were performed starting from (2S)-4-methyleneglutamic acid. Preliminary pharmacological evaluation by measuring IP accumulation using rat forebrain synaptoneurosomes has shown that (2S)-4-(2-phthalimidoethyl)glutamic acid (3a), (2S)-4-(4-phthalimidobutyl)glutamic acid (3b) and 1-[(S)-2-amino-2-carboxyethyl]-3,4-dimethylcyclohex-3-ene-1-carbox ylic acid (8) presented moderate antagonist activities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
127-32
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9871639-Animals,
pubmed-meshheading:9871639-Excitatory Amino Acid Antagonists,
pubmed-meshheading:9871639-Glutamic Acid,
pubmed-meshheading:9871639-Prosencephalon,
pubmed-meshheading:9871639-Rats,
pubmed-meshheading:9871639-Receptors, Metabotropic Glutamate,
pubmed-meshheading:9871639-Synaptosomes
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Synthesis and biological activity of glutamic acid derivatives.
|
| pubmed:affiliation |
Laboratoire des Aminoacides, Peptides et Protéines ESA CNRS 5075, Université Montpellier I & II, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|