|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1999-1-14
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|
pubmed:abstractText |
A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.
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pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
3
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
545-8
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9871615-Antineoplastic Agents,
pubmed-meshheading:9871615-Carcinoma, Small Cell,
pubmed-meshheading:9871615-Humans,
pubmed-meshheading:9871615-Kinetics,
pubmed-meshheading:9871615-Lung Neoplasms,
pubmed-meshheading:9871615-NAD(P)H Dehydrogenase (Quinone),
pubmed-meshheading:9871615-Quinones,
pubmed-meshheading:9871615-Recombinant Proteins,
pubmed-meshheading:9871615-Structure-Activity Relationship,
pubmed-meshheading:9871615-Tumor Cells, Cultured
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1.
|
|
pubmed:affiliation |
School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
