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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-1-14
|
| pubmed:abstractText |
A series of optically active tetrahydro-oxazino[2,3-c]benzopyran derivatives have been synthesized and evaluated for potassium channel opening activity. (4aR,11bR)-1-Benzoyl- 5,5-dimethyl-2,3,4a,11b-tetrahydro-oxazino[2,3-c]benzopyran-9-carb onitrile ((-)-11e) was identified as a bladder-selective potassium channel opener (IC50, bladder = 8.15 microM, IC50, portal vein = 34.5 microM).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
463-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9871599-Adenosine Triphosphate,
pubmed-meshheading:9871599-Animals,
pubmed-meshheading:9871599-Crystallography, X-Ray,
pubmed-meshheading:9871599-Ion Channel Gating,
pubmed-meshheading:9871599-Muscle Relaxation,
pubmed-meshheading:9871599-Nitriles,
pubmed-meshheading:9871599-Portal Vein,
pubmed-meshheading:9871599-Potassium Channels,
pubmed-meshheading:9871599-Rats,
pubmed-meshheading:9871599-Urinary Bladder
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Synthesis of 2,3,4a,11b-tetrahydro-oxazino[2,3-c]benzopyran-9-carbonitriles as ATP-sensitive potassium channel openers.
|
| pubmed:affiliation |
Institute of Pharmaceutical Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|