|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1999-1-26
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|
pubmed:abstractText |
A series of N1-monosubstituted putrescine and spermine derivatives was synthesised using a solid phase methodology. We evaluated their cytotoxicity, calmodulin antagonism and polyamine uptake inhibition, pharmacological properties shared by some antitumoral agents.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
635-40
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9871574-Amine Oxidase (Copper-Containing),
pubmed-meshheading:9871574-Animals,
pubmed-meshheading:9871574-Antineoplastic Agents,
pubmed-meshheading:9871574-Calmodulin,
pubmed-meshheading:9871574-Cattle,
pubmed-meshheading:9871574-Cell Survival,
pubmed-meshheading:9871574-Deamination,
pubmed-meshheading:9871574-Leukemia L1210,
pubmed-meshheading:9871574-Models, Chemical,
pubmed-meshheading:9871574-Oxidation-Reduction,
pubmed-meshheading:9871574-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:9871574-Putrescine,
pubmed-meshheading:9871574-Spermine,
pubmed-meshheading:9871574-Tumor Cells, Cultured
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity.
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|
pubmed:affiliation |
Pharmacochimie de Molécules de Synthèse et de Produits Naturels, Faculté de Pharmacie, Rennes, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
