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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-1-26
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pubmed:abstractText |
A novel series of benzamides with a hexahydro-1,4-diazepine or hexahydroazepine ring in the amine moiety were prepared, and their binding affinities for 5-HT3 and dopamine D2 receptors were evaluated. The R isomer of the 1-ethyl-4-methylhexahydro-1,4-diazepinylbenzamide (R)-22 had potent affinity for both receptors. The R-enantiomer of the corresponding 1-ethylhexahydroazepinylbenzamide 28 showed potent affinity for dopamine D2 receptors with reduced affinity for 5-HT3 receptors, while the S isomer was found to be a potent and selective 5-HT3 receptor antagonist.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/Domperidone,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GR 65630,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Metoclopramide,
http://linkedlifedata.com/resource/pubmed/chemical/Ondansetron,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT3,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Spiperone
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
619-24
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9871571-Animals,
pubmed-meshheading:9871571-Benzamides,
pubmed-meshheading:9871571-Binding Sites,
pubmed-meshheading:9871571-Cerebral Cortex,
pubmed-meshheading:9871571-Corpus Striatum,
pubmed-meshheading:9871571-Domperidone,
pubmed-meshheading:9871571-Dopamine Antagonists,
pubmed-meshheading:9871571-Imidazoles,
pubmed-meshheading:9871571-Indoles,
pubmed-meshheading:9871571-Ligands,
pubmed-meshheading:9871571-Metoclopramide,
pubmed-meshheading:9871571-Models, Chemical,
pubmed-meshheading:9871571-Ondansetron,
pubmed-meshheading:9871571-Rats,
pubmed-meshheading:9871571-Receptors, Dopamine D2,
pubmed-meshheading:9871571-Receptors, Serotonin,
pubmed-meshheading:9871571-Receptors, Serotonin, 5-HT3,
pubmed-meshheading:9871571-Serotonin Antagonists,
pubmed-meshheading:9871571-Spiperone,
pubmed-meshheading:9871571-Stereoisomerism
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pubmed:year |
1998
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pubmed:articleTitle |
A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin- 3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors.
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pubmed:affiliation |
Discovery Research Laboratories I, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
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pubmed:publicationType |
Journal Article
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