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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-1-26
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pubmed:abstractText |
In the present paper, we report the synthesis and the binding profile on 5-HT1A, alpha 1 and D2 receptors of a new series of imide-arylpiperazines 3. The study of the length of the alkyl chain and the imide substructure allows us to suggest some important differences between the no-pharmacophoric sites of both 5-HT1A and alpha 1-adrenergic receptors, which could be of great importance in order to design new selective ligands.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidinones,
http://linkedlifedata.com/resource/pubmed/chemical/Raclopride,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Salicylamides,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
581-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9871564-Adrenergic alpha-Antagonists,
pubmed-meshheading:9871564-Animals,
pubmed-meshheading:9871564-Cerebral Cortex,
pubmed-meshheading:9871564-Corpus Striatum,
pubmed-meshheading:9871564-Dopamine Antagonists,
pubmed-meshheading:9871564-Ligands,
pubmed-meshheading:9871564-Models, Chemical,
pubmed-meshheading:9871564-Prazosin,
pubmed-meshheading:9871564-Pyrrolidinones,
pubmed-meshheading:9871564-Raclopride,
pubmed-meshheading:9871564-Rats,
pubmed-meshheading:9871564-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:9871564-Receptors, Dopamine D2,
pubmed-meshheading:9871564-Receptors, Serotonin,
pubmed-meshheading:9871564-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:9871564-Salicylamides,
pubmed-meshheading:9871564-Serotonin Receptor Agonists,
pubmed-meshheading:9871564-Stereoisomerism,
pubmed-meshheading:9871564-Structure-Activity Relationship
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pubmed:year |
1998
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pubmed:articleTitle |
1-[omega-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5- pyrrolidinediones as 5-HT1A receptor ligands: study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity.
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pubmed:affiliation |
Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain. mluzlr@eucmax.sim.ucm.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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