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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1999-1-26
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pubmed:abstractText |
The two geminal ethyl groups in the succinic acid moiety of CGP57698 (4-[3-(7-fluoro-2-quinolinyl-methoxy)phenyl-amino]-2,2-diethyl-4-oxo- butanoic acid) are responsible for the high in vitro and in vivo potency of this peptidoleukotriene antagonist of the quinoline type. The synthesis and structure activity relationships of CGP57698 and its analogs are described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
965-70
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9871521-Animals,
pubmed-meshheading:9871521-Anti-Asthmatic Agents,
pubmed-meshheading:9871521-Biological Availability,
pubmed-meshheading:9871521-Bronchoconstriction,
pubmed-meshheading:9871521-Callithrix,
pubmed-meshheading:9871521-Guinea Pigs,
pubmed-meshheading:9871521-Indicators and Reagents,
pubmed-meshheading:9871521-Leukotriene Antagonists,
pubmed-meshheading:9871521-Leukotriene D4,
pubmed-meshheading:9871521-Leukotriene E4,
pubmed-meshheading:9871521-Molecular Conformation,
pubmed-meshheading:9871521-Molecular Structure,
pubmed-meshheading:9871521-Quinolines,
pubmed-meshheading:9871521-Rats,
pubmed-meshheading:9871521-Structure-Activity Relationship
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pubmed:year |
1998
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pubmed:articleTitle |
Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class.
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pubmed:affiliation |
Research Department, Novartis Pharma AG, Basel, Switzerland. andreas.von_sprecher@pharma.novartis.com
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pubmed:publicationType |
Journal Article
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