|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1999-1-26
|
|
pubmed:abstractText |
Pyridone-based peptidomimetic inhibitors of recombinant human Interleukin-1 beta-converting enzyme (ICE, caspase-1) with an aminomethylene ketone activating group in the P1' position are described. Several analogues with sub-nanomolar Ki's versus ICE and improved aqueous solubility are reported.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:AshworthD MDM,
pubmed-author:BattA RAR,
pubmed-author:BaxterA JAJ,
pubmed-author:BenziesD WDW,
pubmed-author:ElliotL HLH,
pubmed-author:EvansD MDM,
pubmed-author:FranklinR JRJ,
pubmed-author:HudsonPP,
pubmed-author:IsomuraYY,
pubmed-author:JenkinsP DPD,
pubmed-author:PittG RGR,
pubmed-author:RookerD PDP,
pubmed-author:SempleGG,
pubmed-author:YamamotoSS
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
21
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
959-64
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Peptidomimetic aminomethylene ketone inhibitors of interleukin-1 beta-converting enzyme (ICE).
|
|
pubmed:affiliation |
Department of Medicinal Chemistry, Ferring Research Institute, Chilworth Research Centre, Southampton, U.K.
|
|
pubmed:publicationType |
Journal Article
|
